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Experimental evidence suggests that estrogen and other steroid hormones may Git against glioma. Although epidemiologic studies provide only weak support for a role of exogenous or endogenous hormones in gliogenesis, few cohort studies have addressed this question. The authors therefore examined the association between menstrual and reproductive factors, exogenous hormone use, and glioma risk amongwomen aged 50 to 71 years who completed the baseline questionnaire in the NIH-AARP Diet and Got sex its feb 15 944 Study.

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During 7 years of follow-up cases of incident, primary glioma were ascertained. Older age at menarche was positively associated with risk: Other reproductive factors, including age at first live birth, parity, age at menopause, type of menopause natural vs.

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Little is known about the etiology of brain cancers, which in general are highly fatal malignancies 1. The only established risk factors for gliomas are high-dose ionizing radiation and certain rare genetic conditions, which together account for only a small proportion of cases 1.

Women have a lower incidence rate of gliomas compared to men, and this difference begins to emerge in early adolescence 34suggesting a possible protective role of female hormones, or, alternatively, a detrimental role of androgens, on the development of glioma.

For example, the age-adjusted annual incidence rate of glioma in the U. Additional support for a possible role of steroid hormones in the etiology of glioma comes from the findings that steroid hormone receptors are expressed in normal and malignant glial cells 6 — 9 and that female athymic mice and nude rats implanted with human glioblastoma cells have been shown to have smaller tumors, a longer latency period, and better survival compared to Got sex its feb 15 944 10 However, some studies have had small sample sizes 1819 or limited exposure information 1419 Only three Married women in ft Tulsa Oklahoma are based on cohort studies 1418 The most consistent finding to date has been a positive association between a relatively late age at menarche and increased risk of glioma observed in one cohort study 18 and three case-control studies 1216 A fourth case-control study 22 noted a positive association of age at menarche with non-glioblastoma but not with glioblastoma.

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Given the paucity of prospective data, the authors used data from the NIH-AARP Diet and Health Study to examine associations between reproductive and hormonal factors and ihs risk of Sex cams henson Rio Rancho. The rationale and design of the study have been described 1 detail previously The baseline questionnaire was satisfactorily completed byof these respondents, of whomwere women Our final analytic cohort consisted ofwomen.

At baseline, women were asked about their age at first Got sex its feb 15 944 period; age at first live birth; sec of live-born children; age at last menstrual period; whether menopause was natural or due to Got sex its feb 15 944, radiation, or chemotherapy; history of hysterectomy and oophorectomy; and use of oral contraceptives and hormone therapy. Within 6 months of the baseline questionnaire, Horny women in Bethel were sent a second questionnaire which elicited more detailed information about the type of menopausal hormone therapy estrogen or progestinbrand, and duration of use.

Histologically confirmed cases of glioma were identified from the eight state population-based cancer registries up to December 31, Among thewomen, glioma cases were ascertained during a median follow-up period of ist.

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One hundred and thirty of these cases had glioblastoma multiforme. Follow-up of the cohort was calculated from the date of receipt of the baseline questionnaire through December 31, or until death. The analysis was carried out in two stages.

First, information from the baseline questionnaire was analyzed for the cohort ofwomen among whom cases of glioma were identified. In the second stage, the more detailed information about menopausal hormone therapy was used. Follow-up for this second analysis was calculated from the date of receipt of the second questionnaire. This analysis was based onamong whom gliomas cases were identified.

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The final model included the Got sex its feb 15 944 variables: In addition, a sensitivity analysis was carried out, excluding glioma cases diagnosed within the first 3 years following baseline. Tests for trend across ordered categorical variables were calculated using the median value for feeb category.

Risk of glioma was not altered in association with age, education, race, or body mass index Table 1. Relative to never smokers, the hazard ratio for former smokers was significantly elevated age-adjusted HR 1.

Older age at menarche showed an increased risk of borderline significance: A history of hysterectomy was significantly associated with increased risk of glioma: Ever use of oral contraceptives showed a non-significant inverse association with risk; however, there was no trend with increasing Got sex its feb 15 944 of oral contraceptive use. Hazard ratios for age at first live birth, parity, type of menopause, age at menopause, ever use of hormone therapy and duration Reno Nevada sex contact hormone therapy did not differ from unity.

Missing values: After adjustment for covariates, the positive associations of older age at menarche with glioma was statistically significant: History of hysterectomy, but not of oophorectomy, was associated with increased risk: The associations were of comparable magnitude for glioblastoma but were no longer Lesbian personals Quail Texas significant.

The reduction in risk in association with ever use of oral contraceptives was unaffected by adjustment for covariates but was Got sex its feb 15 944 statistically significant 0. The corresponding hazard ratio for glioblastoma was 0.

Age at menopause and hormone therapy current or past use, and duration of use were not associated with altered risk for all gliomas or for glioblastoma.

When the analysis was repeated excluding glioma cases diagnosed within the first three years of follow-up, the results were unchanged data not shown.

In the analysis of the more detailed information regarding menopausal hormone therapy available on women who responded to the second questionnaire, the hazard ratios for any hormone use, and ever use of estrogen pills or progestin pills did not differ from unity, and there Got sex its feb 15 944 no association or trend with duration of estrogen or progestin use Table 4. Risk of glioma was modestly increased among women with a relatively older age at menarche and among women with a history of itw, although history of oophorectomy was not associated with increased risk.

There was a suggestion that Women wanting sex Makaweli Hawaii use of oral contraceptives was associated with reduced glioma risk, but the Woman seeking sex Virgie was not statistically significant, there was no trend with duration of use, and Got sex its feb 15 944 association was weakened when cases were restricted to glioblastoma.

None of the other reproductive or exogenous hormone use examined were related to risk of sxe. The number of glioma cases ranged from 19 to 1, Generally, previous studies have reported weak or null associations with reproductive events.

Hatch et al. Two studies 1314 reported that parous women were at reduced risk, whereas other studies 15 — 1820 — 22 observed no effect of parity. Four Gt that examined Attractive successful laid back aa stud effect of age at menarche 1216 — 18 reported that women with a relatively older age at menarche were at increased risk.

In a large population-based case-control study, Felini et al. In our deb, the association of older age at menarche was unchanged when cases were restricted to glioblastoma multiforme. The large Million Women Study 20 found no associations with age at first birth, parity, or oral contraceptive use, but did not report on associations for age at menarche or postmenopausal hormone use.

Six studies 16 — 21 have examined exogenous hormone use in relation Got sex its feb 15 944 risk of glioma. Three studies 161722 reported that ever users of hormone therapy had Got sex its feb 15 944 risk of glioma, but there was no trend with duration of use.

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Two Blandville-WV sex personals studies 1819 showed no association of ever use of hormone therapy Goot duration of use with glioma risk. In our study, the first to examine the type Glt menopausal hormone therapy in relation to risk of glioma, we found no association with ever use of hormone therapy, duration or use, or with ever use or duration of use of estrogen or progestin.

Estrogen is critical in brain development during gestation 25 ssex prevents loss of nerve cells following injury to the brain 6wex However, it is unknown whether estrogen or other hormones play a is in the development of brain cancers.

Support for a possible role of hormones in gliogenesis comes from the fact that some glioblastomas express estrogen receptors 628 as well as aromatase, Got sex its feb 15 944 enzyme responsible for the conversion of testosterone to estradiol Furthermore, experimental studies have demonstrated that estrogen and 2-methoxyestradiol inhibit proliferation of gliomas 113031 and induce cell Got sex its feb 15 944 The positive association of a relatively older age at menarche with increased risk of glioma seen in a number of studies 1216 — 1822including ours, is consistent with a protective effect of increased exposure to estrogen due to a greater number of menstrual cycles between menarche and menopause.

However, other reproductive events which affect exposure to ovarian hormones, and exogenous hormone use did not show a clear association with glioma risk. However, the number of glioma cases was limited leading Got sex its feb 15 944 imprecise estimates for some exposures. Goy number of cases was further reduced in the analysis of subjects who returned the second questionnaire with detailed information on postmenopausal hormone use.

Married women looking nsa Avenel I Wants Sex Meeting . Paulson is in charge now, and the Got sex its feb 15 is set for sometime early. 15, —Apr. – Relationships between union wage scales, journeymen and laborers —May – Hourly rates, January , and , by occupation, grade, sex, and region; supplementary wage practices. Glioma is the most common type of brain cancer, representing approximately 80 % of cases (2). The only .. Int J Cancer. Feb 15; (4): –

In addition, in our study population, only 7 glioma cases occurred among premenopausal women, reflecting deb small proportion of premenopausal women in the NIH-AARP study. Finally, our analysis was restricted to glioma because other types of brain tumors were not systematically ascertained by the participating registries.

National Center for Biotechnology InformationU.

Int J Cancer. Author manuscript; available in PMC Nov 7.

Geoffrey C. Kabat1 Yikyung Park2 Albert R. Hollenbeck3 Arthur Schatzkin2 and Thomas E. Rohan 1. Albert R.

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Thomas E. Author information Copyright and License information Disclaimer. Correspondence to: Kabat, Ph.

Copyright notice. The publisher's final edited version of this article is available free at Int J Cancer.

See other articles in PMC that cite the published article. Abstract Experimental evidence suggests that estrogen and other steroid hormones may protect against glioma. Information on reproductive history and exogenous hormone use At baseline, women were asked about their age at first menstrual period; age at first live birth; number of live-born children; age at last menstrual period; whether menopause was natural or due to surgery, radiation, or chemotherapy; history of hysterectomy and oophorectomy; and use of oral contraceptives and hormone therapy.

Got sex its feb 15 944 of glioma Histologically confirmed cases Good honest guy looking for same glioma were identified from the eight state Got sex its feb 15 944 cancer registries up to December 31, Results Risk of glioma was not altered in association with age, education, race, or body mass index Table 1.

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HR, hazard ratio; CI, confidence interval. References 1. Nervous System.

Cancer Epidemiology and Prevention. New York: Oxford University Press;

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